It is not how fit you are, what the course is like, what you ate the night before or anything else. Being under-trained, or overcoming a big hill, or puking out some bad food are often things you can't get over relatively quickly in a race. But the weather on race day is the one variable which will bring you to your knees the hardest.
I have paid special attention to how weather affects performance mostly because of something very specific: I am horrible in warm temperatures. And by "warm" I mean basically anything over 60 degrees. So bad am I when the mercury rises in the ole thermometer that, I was asked to give a speech in Ecuador at a Gatorade Sports Science Institute on sweat loss. In addition, while there, I performed like a gerbil on the treadmill, doing a brisk 45 minute run, indoors, losing seven pounds in sweat alone. (I wish I could tell you how hilarious the owner of the treadmill, who was loaning it to the event, was when he continued to wipe down the outer plastic shell as I ran. Isn't that what the plastic shell is for? He acted as if I had Alien acid sweat that would burn through it if he didn't wipe immediately or thoroughly. But I digress.)
In addition, I have Gilbert's Syndrome. A relatively mild disorder (if you listen to Wikipedia) it comes into play for those of us who do endurance sports as it affects one's ability to recover from strenuous activity. Since I put myself in situations where I push my body further than most people ever have, I would disagree about how mild it is. Nevertheless, you take all of what I have described and suffice it to say I look at the weather app more than I do anything else as race day approaches.
Of my top ten fastest marathons, only one came when the weather was inclement: the Steamtown Marathon in 2007. Run on the day that Chicago infamously had to blackflag its race for heat, how I was able to put this race out of the hat (after a wrong turn added extra miles) is beyond me. In fact, as I look through even the top 25 marathons I have run there are many different things which present themselves. I was in various level of fitness. I ran them over various terrains. Different elevations. Various times of my life. But one things remains the same: nice weather.

OK, so that is anecdotal. It is rather Dane-centric. So don't just look at what works for me. Look at science. Then look again. And again. Wherever you look, it shows you that when the weather is cooler you run better. If it is less humid, you run better. If it is less windy, you run better.
Obviously there are going to be some people who feel they run better in heat and when people just want to "feel" something, you can't tell them otherwise. But the science points to how our bodies warm the ambient air around us by 20 degrees when we run which is why we are told to dress for the run we will be having in the middle rather than the one we start with. Otherwise, you end up sweating so much that your clothes get soaked and even if it is cold when you start, you will be drenched in sweat. Then when you finish you freeze because of all the wet clothing.

So, next time you are looking for that fast race, it may behoove you to check out its historic weather even more than what type of downhill course it has or anything else people use to determine how they will have a good time. Planning for the factor which will probably have the biggest impact on your race, shouldn't be left to chance.
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